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Tremont G, Davis J, Ott BR, Uebelacker L, Kenney L, Gillette T, et al

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Copper peptides are naturally occurring in human plasma

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It argues that the failures of EVOKE and Exenatide-PD3 narrow the hypothesis rather than refute it, pointing toward brain-penetrant compounds, biomarker-anchored endpoints, and patients selected by biology rather than diagnosis