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A groundbreaking 2019 study demonstrated that colonizing ALS mice with Akkermansia muciniphila (a mucin-degrading bacterium usually considered pro-inflammatory in PD/MS contexts) actually ameliorated ALS progression in the mice [83]

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However, as a member of the nightshade (Solanaceae) family, concerns have been raised regarding the potential presence of toxic compounds, such as tropane alkaloids (e.g., atropine) [82] and steroidal alkaloid glycosides (e.g., lyciosides A and B) [83]