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Neuropathic pain is often chronic, and neuropathic symptoms (i.e., component) are frequently reported and aggravate painful, non-primary neurological conditions in spite of no demonstrable neuronal injury (Freo et al., 2019b, Freynhagen et al., 2019

Of the records screened, 40 studies were excluded as they were non-clinical studies (including reviews, editorials, and or conference abstracts)

Common causes include gallstones, heavy alcohol use, or certain medications, but in most cases related to weight loss drugs, it's mild and resolves with treatment

Twelve genes were shared between all drugs on the second level network GHSR, REM1, HTR7, PHF20, MLNR, CCK, HTR3A, GHRL, ATP12A, HTR4, MLN, INS

**Medical supervision** - Peptide therapy should only be used under the care of a licensed provider 2