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Higher levels of MAOA could decrease neurotransmitter levels to maintain balanced levels of these chemicals in the brain.[ref] The MAO-A variants can interact with environmental factors to influence mental health

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Fluid retention and edema: During treatment with glucocorticoids and diclofenac, edema and fluid retention have been observed so the formula must be used with caution in patients with a history of decompensation, hypertension or other factors predisposing to fluid retention