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In addition, melatonin accelerates the emptying effect of the gastrointestinal tract in mice after SCI ( Melatonin regulates intestinal immune function and down-regulates inflammatory response In prolonged paradoxical sleep deprivation mouse model, with the activation of the HPA, a large amount of cortisol were released into the systemic circulation, which would mediate the disturbance of intestinal microbiota (Zhao et al., 2021)

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