Endocrinology 166 (4), bqaf028
For example, all participants in EMPA-REG OUTCOME had established atherosclerotic CVD, compared with approximately 65% of participants in CANVAS, 50% in CREDENCE, and approximately 40% in DECLARE TIMI-58
This acylation is followed by the processing of ghrelin from proghrelin which involves cleavage by proprotein convertase subtilisin/kexin type 1, PCSK1
As MBS leaderand Accomplish Health advisorJOHN MORTON puts it: Combining surgical approaches and GLP-1 receptor agonist therapy presents an opportunity to further improve outcomes for patients undergoing MBS. --- Review: Combining Medications With Bariatric Surgery to Treat Obesity To view or add a comment, sign in Compared with GLP-1 RAs, bariatric metabolic surgery was associated with lower rates of: All-cause mortality Major adverse cardiovascular events (MACE) Nephropathy Retinopathy These findings indicate that even with the availability of GLP-1 RAs, metabolic surgery remains superior to medical treatment for macrovascular and microvascular outcomes in patients with diabetes and obesity
Throughout the follow-up period, HbA1C levels remained consistently higher in the GLP-1 RAs group (Figure S1)
