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The study reported lower risks for several cancers, including hepatocellular, colorectal, breast, and prostate cancers, though it did not find a significant reduction in lung cancer risk.25 So the honest answer is this: current human evidence does not show that NAC causes cancer, but animal and mechanistic research suggests NAC could behave differently depending on cancer type, disease stage, dose, and treatment context

It is marketed as a food or dietary supplement, either alone, or in combination with vitamin C, alpha lipoic acid and other antioxidants

In E9 (R1) Addendum on estimands and sensitivity analysis in clinical trials to the guideline on statistical principles for clinical trials, Proceedings of the international conference on harmonisation of technical requirements for registration of pharmaceuticals for human use, 2019

[DOI] [PubMed] [Google Scholar] 9.Lands LC, Grey VL, Smountas AA

We acknowledge the Elettra-Sincrotrone Trieste (Italy) for support in X-ray data collections and the European Synchrotron Radiation Facility for provision of microscope time on CM01