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This distribution pattern suggests that GLP-1Rs may be involved in the integration of visceral sensory signals, regulation of energy homeostasis, reward-related behaviours, and autonomic nervous system control (42)

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Berberine should not be described as a GLP-1 'activator' in the medicinal sense, as any effects on GLP-1 pathways appear to be indirect and considerably less potent than pharmaceutical GLP-1 therapies