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Preclinical studies have shown that sustained AGE exposure induces hallmark features of diabetic kidney disease (DKD) glomerular hypertrophy, fibrosis, and endothelial dysfunction all significantly reduced in RAGE-deficient mice (112)

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Preliminary clinical data and lab work suggest advantages for fertility, uterine recovery, and ovarian support, though large trials are still sparse

In biochemical research settings, this peptide complex is frequently investigated for its role in copper transport mechanisms and peptide-mediated signaling pathways

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