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Pregnant women, women who are breastfeeding, people with liver disease, people who are on medications for diabetes, alcoholics and people on kidney dialysis are most at risk of a folate deficiency

*Correspondence: LD Brown, [email protected] This article was submitted to Developmental Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Validating non-invasive biomarkers (e.g., urine exosomal ferroptosis-related proteins and circulating lipid peroxide metabolites) that reflect renal ferroptosis activity in CKD patients with RF is urgently needed for early diagnosis and therapeutic monitoring