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Offering insights into brain pathology through minimally invasive methods, these markers are essential not only for early diagnosis and stratification but also for disease monitoring, crucial elements in both clinical care and trial design

We also measured intracellular GSH concentrations, reactive oxygen metabolites, and lipid peroxides

The unexpected finding of decreased NRF2 levels despite elevated oxidative stress markers warrants further investigation into the complex regulatory mechanisms underlying redox homeostasis in Down syndrome pregnancies

Mice were then fed a combination of Western diet with alcohol in the drinking water for 18 weeks (WDA model), control mice were given Western diet with plain water