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This systems-based perspective is exactly what FMU's Functional Medicine 2.0 curriculum teaches the ability to see how every system communicates and compensates when metabolism is under stress

Weight loss and caloric restriction represent the most significant mechanism

The greater magnitudes of bodyweight reduction seen in this trial, as well as the improvements in cardiovascular risk factors and glucose control, can have beneficial effects on health goals in clinical practice. In the STEP UP T2D trial, a higher semaglutide dose resulted in an average bodyweight reduction of 13.2%, compared to 10.4% for the standard dose and 3.9% for the placebo

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