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This corresponds to dose multiples of 9 and 19.5 times, respectively, the maximum recommended human dose (MRHD) of 10 mg/day for amlodipine and 320 mg/day for valsartan (based on body surface area and considering a 60 kg patient)

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Isocarboxazid may lead to transient increases in serum aminotransferase levels in certain patients, but there have been no direct links established between isocarboxazid and instances of drug-induced liver injury

Senolytics A class of therapeutics that induce senescent cell death by targeting their pro-survival pathways