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27 Conversely, ascorbate deficiency has been associated with decreases in glutathione concentrations in humans

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However, participants with normal renal function had a slightly lower total exposure and rate of absorption than participants with renal impairment, but without a trend across the different renal impairment groups

The GCH1/BH4 pathway acts as an endogenous antioxidant pathway, GCH1 protects cells from ferroptosis primarily through the antioxidant action of BH4, and is completely independent of GPX4-mediated protection against ferroptosis [44]