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La vida media prolongada de tirzepatide se debe a modificaciones estructurales especficas: la sustitucin de alanina por cido 2-aminoisobutrico que confiere resistencia a la degradacin por DPP-4, y la conjugacin con un cido graso C20 que permite la unin reversible a la albmina srica, reduciendo la degradacin enzimtica

Endocrinology (2018) 159:157084