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Evaluation of enzyme inhibitors in drug discovery

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The capsule polysaccharide from serogroups A, B, C, W, and Y meningococci inhibits C1q interaction with bound anti-fHbp and anti-porin A antibodies, and, consequently, the deposition of C4b and classical complement pathway (Jarvis and Vedros, 1987), as well as LOS sialylation (Vogel et al., 1997), limits C3 deposition, inhibiting the alternative pathway

Antitumor effects of chloroquine/hydroxychloroquine mediated by inhibition of the NF-B signaling pathway through abrogation of autophagic p47 degradation in adult T-cell leukemia/lymphoma cells

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