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showed that in senescent bladder cancer cells of the Ejp21 and Ejp16 lines, 107 and 132 unique plasma membrane proteins, respectively, were detected - proteins absent in non-senescent cancer cells [23]

5 Modulation of energy metabolism and activation of the immune system as targets of natural products Substantial studies highlight the antineoplastic effect of natural products in addition to their use in the development of new drugs (Newman and Cragg, 2016

A randomized clinical trial is currently investigating whether doxycycline can limit the NF-B dependent release of pro-inflammatory cytokines and thereby prevent evolution towards ARDS in patients with COVID-19 (ClinicalTrials

Importantly, astrocytes obtained from various brain regions differ in their capacities to stimulate neuronal migration, survival, growth, and uptake of extracellular glutamate, aspects that are critical in the pathology of ALS [90, 97, 98]