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For instance: people with obesity are more likely to develop type 2 diabetes people with obesity are at an increased riskof developing Alzheimers later in life people with type 2 diabetes are also more likely to develop Alzheimers disease Alzheimers disease is associated with insulin resistance in the brain, with some scientists referring to Alzheimers as type 3 diabetes obesity, type 2 diabetes, and Alzheimers all involve inflammation, and GLP-1 agonists have an anti-inflammatory effect studies in animal models of dementiahave shown that GLP-1 agonists can protect rats brains from damage

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Legge F, Paglia A, DAsta M, Fuoco G, Scambia G, Ferrandina G

Nausea and constipation show up, usually mild and usually fading with a slow ramp

In addition to lowering the expression of genes linked to osteoclast activity, VDR activation in osteoclasts lowers the synthesis of RANKL and M-CSF, preventing osteoclast development and subsequent bone resorption (144)