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In the transformation of hemorrhage after cerebral ischemia, iron overload significantly decreases oxidation metabolism, lactic acid generation, and brain pH value, further increasing iron release

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Furthermore, ISCU knockdown disrupted ISC assembly, impairing M2 polarization in vitro by altering arginine metabolism, and promoting iron accumulation and ferroptosis [69]

Inflammatory Bowel Disease Inflammatory bowel disease, such as the aforementioned Crohns disease and ulcerative colitis, may be treated with corticosteroids

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