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Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals
For instance, a patient with borderline low B-vitamin levels might receive 0.5 mL IM weekly, whereas someone with severe malabsorption could receive 1-2 mL IM two to three times per week initially
Preclinical studies in obese animal models further indicate that AOD 9604 enhances lipolytic activity within adipose tissue, with preferential effects observed in metabolically dysregulated fat cells [2]
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LEfSe analysis provided a secondary measure to establish differences between treatment groups in addition to the one-way ANOVA/KruskalWallis tests performed on each genus/phylum
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