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This selective binding initiates both genomic and non-genomic estrogenic responses that disrupt normal hormonal balance ( 3.1.2 Membrane receptor and calcium signaling dysregulation 3.1.2.1 Calcium homeostasis disruption EED exposure significantly disrupts intracellular calcium homeostasis, leading to aberrant Ca 2+ signaling patterns that compromise sperm function

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Another study in agricultural workers from East Texas identified a significant increased risk (OR = 10.9) of PD with the continuous use of rotenone [53]

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