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10 Moreover, neutrophils can phagocytose uric acid crystals and release various inflammatory mediators, such as interleukin-1 and ROS, further activating inflammation and amplifying the local inflammatory response

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Based on Phase 2 trial data, nausea associated with retatrutide is most common during the early weeks of treatment or following each dose increase, and typically diminishes over time as the body adjusts to the medication