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Abstract Alcohol and other substance use disorders (ASUDs) are complex, multifaceted, but treatable medical conditions with widespread medical, psychological, and societal consequences

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Unimolecular peptides with dual GIP/GLP-1 receptor agonism have been developed to improve metabolic efficacy and therapeutic index beyond what incretin mono-agonists can achieve (44, 63)

Experimental groups The experimental rats were randomly categorized into four groups as healthy control (HG), ATP alone (ATPG), hydroxychloroquine alone (HCQG), ATP + hydroxychloroquine (AHQG), with six animals in each group