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The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity
The later nanoprobe may further swell in response to the acidic microenvironment after targeting the tumor site, heightening the LFUS-induced cavitation effect of BEAGA/ApoE-PDHD (Fig
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Cell 169 , 286300.e16 (2017)
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