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Ignoring Sterility: Reusing a syringe, not wiping the stoppers, working in a dusty area these are all invitations for bacteria

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Advice for small peptides versus bigger biologics is different in each region, and alterations to immunogenicity testing or potency assays can necessitate study repeats

Durability of effect: A large real-world head-to-head analysis presented at ASMBS 2025 found patients lost ~5 more weight at 2 years with sleeve or bypass than with semaglutide/tirzepatide (about 24% vs 4.77% ), reflecting high discontinuation and adherence challenges with weekly injections