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The cardioprotective properties, weight loss, and blood glucose control can be significant

Furthermore, unlike long-acting GLP-1 analogs that also signal through the incretin pathway, DPP-4 inhibitors do not require parenteral administration, and their long-term use is associated with a low risk of gastrointestinal adverse effects and no meaningful increases in heart rate [37,38,39,40]

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And so I've seen issues where people become pretty profoundly dehydrated on the medication because they're not feeling great, they forget to hydrate, et cetera

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