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For cardiomyopathy, GLP-1RAs improve mitochondrial function via regulating autophagy and inflammatory signaling, as well as not only mediate the inhibition of myocardial apoptosis, but also improve cardiac energy metabolism

Semaglutide protects against 6-OHDA toxicity by enhancing autophagy and inhibiting oxidative stress

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Prospective, longitudinal studies are needed to further elucidate these effects and optimize perioperative strategies in orthopedic populations

These changes may result in muscle mass reduction, potentially leading to osteosarcopenia, which could increase the risk of fracture owing to an elevated likelihood of falls