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This was supported by another study in which liraglutide attenuated the TNF or high-glucose-mediated induction of PAI-1, ICAM-1, and VCAM-1 expression in human vascular endothelial cells, the proposed molecular mechanism underlying this effect may involve the regulation of NUR77 expression [61], which is a nuclear receptor and transcription factor involved in regulating gene expression related to cell growth, apoptosis, metabolism, and inflammation

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In addition, a once-weekly insulin icodec/semaglutide combination is currently under global development, including in Japan [54]

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