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Conversely, bile acids also affect the gut microbiota through activation of the innate immune system and production of antimicrobial peptides (127)

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We use the Charles River Endosafe PTS system to test for bacterial endotoxins following USP guidelines: The following are suitability parameters that verify the system was working properly and the sample prep dilution is appropriate for accurate results

Neuroimaging studies in healthy subjects have documented measurable changes in brain network activity following intranasal administration

## Storage After Reconstitution - **Refrigerate** at 36-46 degrees F (2-8 degrees C) immediately after reconstitution - **Use within 28-30 days** - **Protect from light** -- store in the original box or wrap in foil - **Never freeze** reconstituted solution - **Check before each use** -- if cloudy, discolored, or containing particles, discard ### Before Reconstitution (Unreconstituted Powder) - Refrigerate or store at controlled room temperature per the label - Check expiration date - Keep dry and protected from moisture ## Injection Technique ### Preparing Your Dose 1