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Some patients may restart at the same dose while others may require a lower dose after a longer treatment break to reduce nausea and digestive side effects

Importantly, patients should seek urgent medical advice if they experience severe, persistent abdominal pain (which may radiate to the back) with or without vomiting, as this could indicate pancreatitis a rare but serious adverse effect noted in the SmPC

Through these combined hormonal actions, ZepBound restores metabolic signaling patterns that are often disrupted in individuals with obesity or insulin resistance

The ongoing Phase 3 programme known as the TRIUMPH trials is evaluating retatrutide across a broader population, including individuals with obesity, type 2 diabetes, and cardiovascular risk factors

Most patients self-inject DSIP subcutaneously at home before bedtime