Huberman highlights its benefits not only for muscle maintenance but also for cognitive function, explaining that " creatine is actually a brain boosterit enhances ATP production in the brain, improving cognitive function ." Joe Rogan, an advocate for strength and conditioning, takes creatine to support muscle retention and physical performance, especially as he ages
Supplementation in high doses (over 1000 mg) relatively shortly before training appears to be advisable, as circulating L-carnitine - in contrast to muscle carnitine - presumably has a vascular-protective effect against oxidative damage in the microvascular area
Uniquely, it had a time period at the end of the study where study medication was discontinued for 12 weeks, then reassessed to see if the treatment effects persisted
TGF- signaling Fibrosis is driven by a complex interplay of pathological processes, including activation of TGF-, dysregulated chemokine expression, metabolic dysfunction, cellular senescence, mitochondrial and endoplasmic reticulum (ER) stress, autophagy, DNA damage, and apoptosis [20, 33, 36, 37]
Functional Characterization of Des-IGF-1 Action at Excitatory Synapses in the CA1 Region of Rat Hippocampus. Journal of Neurophysiology, vol
