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Jiang T, Sun Q, Chen S
Phase 3 trials are currently ongoing and will provide data on longer treatment durations, maintenance protocols, and discontinuation outcomes specific to retatrutide
Effects on Mood and Anxiety Large clinical trials of semaglutide at a 2.4 mg dose found no consistent rise in depression or anxiety, even when assessed with tools like the PHQ-9 and Columbia-Suicide Severity Rating Scale
In this study, participants were allocated to receive either lorcaserin - a selective 5-HT 2 C receptor agonist that increases satiety by activating hypothalamic pro-opiomelanocortin neurons - or a placebo [38]
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