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Research indicates that insulin-resistant patients exhibit decreased mitochondrial oxidative capacity in skeletal muscle and downregulated BCAA catabolic enzyme expression, leading to accumulation of BCAAs and branched-chain acylcarnitines (114)

Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, et al

F.KangH.WoolfP.HurstW.CamachoF.et al (2005)

Conclusion: Taken together, our findings suggest that disruption in cholinergic cortical pathways attributable to SVD, rather than cholinergic thalamic pathways, contributed to the motoric cognitive dysfunction in patients with SVD

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