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Commenters also asserted that the proposed approach is not actually market-based due to a lack of competing hospitals and/or a lack of competing MAOs in many areas

doi: 10.1038/s41422-020-00441-1 6 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

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These approaches address the underlying goals without the documented risks of invasive procedures, providing genuine health benefits backed by research rather than anecdotal claims

Given the substantial resource demands of drug development, large sample sizes, extended trial durations, and the financial and physiological burden of certain treatments (e.g., monoclonal antibodies targeting A), it is ethically and scientifically imperative to identify patients for whom benefit is plausible and to avoid unnecessary exposure of those unlikely to respond