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Of concern, is the novel finding that chronic exposure to HFSD during adulthood, consistently downregulates PPG mRNA expression (but not GLP-1R)
doi: 10.2337/dc16-0690 28 MathieuCZinmanBHemmingssonJUWooVColmanPChristiansenEet al
It is typically present since childhood but may change during puberty or pregnancy
Bioactive plant compounds, such as curcumin and resveratrol, inhibit DPP-4 activity in vitro and in diabetic animal models, which can prolong the active form of GLP-1 and contribute to improved glycemic control and modest weight effects in preclinical settings
Our genetic epidemiological findings suggest that in the historically artisanal and smallscale gold mining study population, the genetic variants analyzed in the glutathione-related genes could modulate the pathogenesis of Hg nephrotoxicity by controlling the glutathione concentrations
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