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Patients should be informed about how Semaglutide works and its benefits

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For women who have not achieved adequate results with conservative measures, bariatric surgery may be considered in severe obesity (BMI 40 kg/m or 35 kg/m with comorbidities) after assessment in specialist Tier 3 weight management services, as per NICE guidance

While high affinity is often desired, the synergy between independent metabolic pathwaysnamely GLP-1 (Glucagon-like peptide-1), GIP (Glucose-dependent insulinotropic polypeptide), and GCGR (Glucagon receptor)determines the ultimate metabolic outcome

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