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Preserving normal pulsatile release of GH is critical to ensuring that proper release of downstream hormones, such as insulin-life growth factor-2 (IGF-1)

Table 1: Retatrutide Binding Affinity (Ki values) Table 2: Retatrutide Functional Potency (EC50 values) The binding kinetics reveal that retatrutide exhibits highest affinity for the glucose-dependent insulinotropic polypeptide receptor, with a human Ki value of 0.057 nM, representing exceptional binding strength [6] [7] [8]

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