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GIP Receptor GIP exerts its biological properties by binding to its specific receptor, which in addition to pancreatic islets, is localized to adipocytes, enterocytes, inner layers of the adrenal cortex, bone, heart, and various parts of the brain, including the cerebral cortex, pituitary, hippocampus, olfactory bulb, and hypothalamus (57)

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PGC-1, peroxisome proliferator-activated receptor coactivator-1

Meeting these criteria helps doctors determine which patients are most likely to benefit from prescription therapy

Additionally, the animal model utilized in our study represents a chronic heroin dependence model, and its relevance to heroin addiction requires further investigation