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The imbalance between production and quenching of these reactive substances through antioxidant mechanisms causes oxidative stress

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Medical societies, including the American Medical Association, have formally acknowledged that BMI is an imperfect measure of adiposity and metabolic health

In accordance with previous reports 36,37 , our GSEA analysis revealed positive enrichment for genes of the mTORC1 signaling pathway in Gclc -sufficient MZB compared to FoB (Fig