These can be more common than blood sugar changes and can include symptoms like nausea, vomiting, and diarrhea
The back-to-back arguments on tirzepatide, the active ingredient in Eli Lillys Mounjaro and Zepbound, and the related semaglutide case, Novo Nordisks Ozempic and Wegovy, boiled down to two questions: Did the FDA follow the right procedure, and did it actually look at the facts fairly
In patients with type 2 diabetes inadequately controlled on metformin immediate-release alone, the overall incidence of adverse reactions of hypoglycemia was 1.3% in patients given add-on sitagliptin and 2.1% in patients given add-on placebo
However, some patients do experience thirst while taking these medications, typically as an indirect consequence of gastrointestinal side effects such as nausea, vomiting, or diarrhea, which can lead to dehydration
The combination of behavioral therapy and the magnitude of change makes this a signal worth paying attention to, even with the study constraints
