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The maximum dose of semaglutide used for the treatment of obesity is 2.8 mg/week (0.4 mg/day), whereas the maximum dose for the treatment of T2DM is 1 mg/week

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Drugs can fail at any phase of clinical trials due to various factors

Specifically, individual treatment with the amylin agonist sCT or with the GLP-1R agonist, liraglutide, successfully decreased 24 h body weight change and food intake at 1, 3, 6 and 24 h post-injection (Fig