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[...] Nitrofurantoin is a lipid-soluble weak acid with a pKa value that is somewhat favorable for diffusion into prostatic fluid [78]

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We experiment with the model by changing the inputs or changing parameters (for example, a parameter that gives the strength of a particular allosteric interaction) and determine what the effect is

doi: 10.1093/hmg/ddh180

So far, none of this has deterred Johnson, who has spent two years fine-tuning what he calls Blueprint, a system of behaviours designed to take better care of him than his own mind can