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In this review, we emphasize on (1) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (2) importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID-19 disease, (3) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (4) new therapies that include antioxidant defenses restoration

PMID: 23873438 Dhonukshe-Rutten RA et al

Nguyen MT, Fernando S, Schwarz N, Tan JT, Bursill CA, Psaltis PJ

Often called the bodys master antioxidant, it plays an important role in: Cellular health: helping to protect cells from free radical damage Detoxification: supporting liver function and toxin removal Immune function: regulating immune system responses and reducing inflammation Oxidative stress reduction: neutralising harmful reactive oxygen species Glutathione is made from three amino acids, which makes it a tripeptide

There is no clear scientific support for pre-workout dosing as a protective strategy