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Biochemical hyperandrogenism is confirmed by elevated total or free testosterone levels or both, measured using liquid chromatography mass spectrometry and tandem mass spectrometry assays (which are preferred over direct immunoassays), or elevated androstenedione or dehydroepiandrosterone sulfate

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Notably, SYK treatment down-regulates the expression of genes related to inflammation, proliferation, fibrosis and migration in fibroblast subpopulations implicated in scarring