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While we expanded our analysis to include additional follow-up data and performed sensitivity analyses with broader inclusion criteria, we acknowledge that limitations related to sample size remain, particularly for certain subgroup analyses

Many of these metal-based mimics effectively react with a wide range of free radicals, and their specificity for hydrogen peroxide is rather limited

Immediate medical attention is warranted if any of the following symptoms develop: Jaundice : yellowing of the skin or whites of the eyes, which may indicate significant liver dysfunction or bile duct obstruction Severe abdominal pain : particularly in the right upper quadrant or pain radiating to the back, which could suggest gallbladder problems, pancreatitis or other hepatobiliary complications Fever with abdominal pain : which may indicate cholecystitis (gallbladder inflammation) Dark urine accompanied by pale stools : suggesting impaired bile flow Unexplained bruising or bleeding : potentially indicating reduced synthesis of clotting factors by the liver For these symptoms, patients should contact NHS 111, seek same-day GP assessment, or attend A&E if symptoms are severe

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