Key research themes involving glutathione include: Scavenging of free radicals (e.g., peroxides, nitrogen dioxide, hypochlorous acid) Support of other antioxidant systems (e.g., vitamin C and vitamin E recycling) Detoxification via glutathione S-transferases and related enzymes Regulation of protein folding, disulfide-bond formation, and thiol redox status Modulation of inflammatory mediators, nitric oxide pathways, and cellular metabolism Because endogenous glutathione synthesis capacity appears to decrease with age in many models, glutathione is frequently used as both an experimental variable and a biomarker in studies of aging, disease susceptibility, and redox imbalance
Figure 1 3.2 Inclusion of literature characteristics The included studies were coded in Excel
Sepesi B, Cuentas EP, Canales JR, Behrens C, Correa AM, Vaporciyan A, Weissferdt A, Kalhor N, Moran C, Swisher SG , Wistuba I
Nanotechnology The nanotechnology-based approach is an emerging strategy for the development of therapies targeting tumor angiogenesis which could improve the current pharmacokinetic profiles of anti-angiogenic drugs and favor their selective accumulation in tumors (Darweesh et al., 2019)
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