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Interestingly, we also found that the hypoxia-induced decline in PP2A activity was reversed when -syn or p--syn was interfered with, suggesting that hypoxia-induced PP2A inhibition and -syn pathology are mutually reinforcing vicious cycles

Proc Natl Acad Sci U S A , 109 (3), 911916

Kayser-Fleischer rings Kayser-Fleischer rings Copper deposits in Descemets membrane of the cornea, manifested as green-brown rings that encircle the iris

Those have causes that can be measured and treated right now, and addressing them makes any future peptide protocol work better

It binds toxic metabolites so they can be excreted through bile or urine