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The observed metabolic-research differences between the two compounds are therefore not explainable by tirzepatide hits GLP-1 harder. They are explainable by the synergistic effect of dual-receptor engagement, where GIPR activation amplifies the downstream consequence of a lower-affinity GLP-1R hit

[1] According to the FDA-approved prescribing information, semaglutide must be administered subcutaneously into the abdomen, thigh, or upper arm

doi: 10.1038/ijo.2013.120 94 BodeB

If you click through the social media ad, theyve got bold red letter alerts telling me to Stock up before the FDA halts sales of semaglutife April 22! This is not ok (even if their lawyers have determined the messaging is legal) and health professionals should warn their patients to be very skeptical of these types of ads

The paradigm for treating people with obesity has often been to recommend lifestyle changes, and then if they develop diabetes or another metabolic condition, to treat them with metformin, insulin, or GLP-1 drugs, says study senior and corresponding author Andrew Stokes, associate professor of global health