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We found that Gstp / mice displayed a higher mortality rate, severer acute lung injury and higher HMGB1 release level than wild type C57BL/6 mice after CLP surgery (Figures 1AC), which first demonstrated that GSTP acted as a key negative regulator in sepsis development

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Unlike traditional small-molecule drugs, biologics are typically larger and more complex, offering targeted treatment strategies with high specificity and fewer off-target effects

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