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2 and 3 of the ESM)

Food fails to suppress ghrelin levels in obese humans

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ATP channel, increasing K ATP channel sensitivity to ATP and leading to K ATP channel closure, cell membrane depolarization and VDC channel opening, followed by Ca 2+ influx through VDC channels into cells to promote the exocytosis of insulin granules and the acute secretion of insulin and into circulation (Mller et al., 2019) (Figure 2)

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